Comprehensive Analysis of Parasite Biology : From Metabolism to Drug Discovery

Sylke Muller

This most recent volume in the series on Drug Discovery in Infectious Diseases focusses on the use of metabolic analysis of protozoic parasites for rational drug discovery design. Covering all classes of parasites, this ready reference covers such methodologies as virtual compound, high throughput, and cellular screening, as well as computer-assisted and structure-based drug design, and pathway modelling. Furthermore, several chapters focus on the latest technologies increasingly being used to dissect metabolic pathways and cellular processes, while enzymatic drug targets for which structural, knock out and inhibitor data are available are also included as well as recent antiparasitic agents targeting particular pathways serving as lead compounds for further drug development. With its real-life success stories, this is a must-have for all professionals dealing with drug discovery in parasitology.

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